We have applied genomic, computational, and molecular approaches towards understanding basic mechanisms of nuclear receptor biology and their impact on human diseases. Our research has specifically focused on estrogen receptors (ERs) and their role in breast cancer. We have worked both independently and also with a number of collaborators in utiliz microarrays, binding site modeling, and chromatin immunoprecipitation (ChIP) to study transcriptional regulatory mechanisms and gene expression profiles associated with disease outcomes in patient samples. Findings from these studies have been published in peer-reviewed journals across multiple disciplines. Using the experimental approaches and tools developed and refined in our studies of ERs in breast cancer, we look to expand our efforts towards characterizing other nuclear receptors and their roles in biological and pathogenic processes.